The glial marker YKL-40 is decreased in synucleinopathies.
Identifieur interne : 000737 ( Main/Exploration ); précédent : 000736; suivant : 000738The glial marker YKL-40 is decreased in synucleinopathies.
Auteurs : Bob Olsson [Suède] ; Radu Constantinescu ; Björn Holmberg ; Niels Andreasen ; Kaj Blennow ; Henrik ZetterbergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Adipokines (blood), Adipokines (cerebrospinal fluid), Aged, Analysis of Variance, Antigens, CD14 (blood), Antigens, CD14 (cerebrospinal fluid), Basal Ganglia Diseases (blood), Basal Ganglia Diseases (cerebrospinal fluid), Female, Humans, Lectins (blood), Lectins (cerebrospinal fluid), Male, Middle Aged, Multiple System Atrophy, Neurodegenerative Diseases (blood), Neurodegenerative Diseases (chemically induced), Parkinson Disease, Supranuclear Palsy, Progressive, Tauopathies (blood), Tauopathies (cerebrospinal fluid), alpha-Synuclein (blood), alpha-Synuclein (cerebrospinal fluid).
- MESH :
- chemical , blood : Adipokines, Antigens, CD14, Lectins, alpha-Synuclein.
- chemical , cerebrospinal fluid : Adipokines, Antigens, CD14, Lectins, alpha-Synuclein.
- blood : Basal Ganglia Diseases, Neurodegenerative Diseases, Tauopathies.
- cerebrospinal fluid : Basal Ganglia Diseases, Tauopathies.
- chemically induced : Neurodegenerative Diseases.
- Aged, Analysis of Variance, Female, Humans, Male, Middle Aged, Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
Abstract
Microglia are resident immunosurveillant cells in the central nervous system, and astrocytes are important for blood flow, plasticity, and neurotransmitter regulation. The aim of this study was to investigate whether astrocyte and microglial activation, estimated through markers in cerebrospinal fluid and serum, differed between synucleinopathies, tauopathies, and controls.
DOI: 10.1002/mds.25589
PubMed: 23847144
Affiliations:
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Le document en format XML
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Holmberg</name></author><author><name sortKey="Andreasen, Niels" sort="Andreasen, Niels" uniqKey="Andreasen N" first="Niels" last="Andreasen">Niels Andreasen</name></author><author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name></author><author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23847144</idno><idno type="pmid">23847144</idno><idno type="doi">10.1002/mds.25589</idno><idno type="wicri:Area/PubMed/Corpus">000842</idno><idno type="wicri:Area/PubMed/Curation">000842</idno><idno type="wicri:Area/PubMed/Checkpoint">000760</idno><idno type="wicri:Area/Ncbi/Merge">003C40</idno><idno type="wicri:Area/Ncbi/Curation">003C40</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C40</idno><idno type="wicri:Area/Main/Merge">000737</idno><idno type="wicri:Area/Main/Curation">000737</idno><idno type="wicri:Area/Main/Exploration">000737</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The glial marker YKL-40 is decreased in synucleinopathies.</title><author><name sortKey="Olsson, Bob" sort="Olsson, Bob" uniqKey="Olsson B" first="Bob" last="Olsson">Bob Olsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name></author><author><name sortKey="Holmberg, Bjorn" sort="Holmberg, Bjorn" uniqKey="Holmberg B" first="Björn" last="Holmberg">Björn Holmberg</name></author><author><name sortKey="Andreasen, Niels" sort="Andreasen, Niels" uniqKey="Andreasen N" first="Niels" last="Andreasen">Niels Andreasen</name></author><author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name></author><author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipokines (blood)</term><term>Adipokines (cerebrospinal fluid)</term><term>Aged</term><term>Analysis of Variance</term><term>Antigens, CD14 (blood)</term><term>Antigens, CD14 (cerebrospinal fluid)</term><term>Basal Ganglia Diseases (blood)</term><term>Basal Ganglia Diseases (cerebrospinal fluid)</term><term>Female</term><term>Humans</term><term>Lectins (blood)</term><term>Lectins (cerebrospinal fluid)</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy</term><term>Neurodegenerative Diseases (blood)</term><term>Neurodegenerative Diseases (chemically induced)</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term><term>Tauopathies (blood)</term><term>Tauopathies (cerebrospinal fluid)</term><term>alpha-Synuclein (blood)</term><term>alpha-Synuclein (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adipokines</term><term>Antigens, CD14</term><term>Lectins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Adipokines</term><term>Antigens, CD14</term><term>Lectins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Neurodegenerative Diseases</term><term>Tauopathies</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Tauopathies</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Microglia are resident immunosurveillant cells in the central nervous system, and astrocytes are important for blood flow, plasticity, and neurotransmitter regulation. The aim of this study was to investigate whether astrocyte and microglial activation, estimated through markers in cerebrospinal fluid and serum, differed between synucleinopathies, tauopathies, and controls.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey="Andreasen, Niels" sort="Andreasen, Niels" uniqKey="Andreasen N" first="Niels" last="Andreasen">Niels Andreasen</name><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name><name sortKey="Holmberg, Bjorn" sort="Holmberg, Bjorn" uniqKey="Holmberg B" first="Björn" last="Holmberg">Björn Holmberg</name><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name></noCountry><country name="Suède"><noRegion><name sortKey="Olsson, Bob" sort="Olsson, Bob" uniqKey="Olsson B" first="Bob" last="Olsson">Bob Olsson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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